Article
Gene expression profiling identifies significant differences between the molecular phenotypes of bone marrow-derived and circulating human CD34+ hematopoietic stem cells.
Blood - 15 Mar 2002
Steidl Ulrich, Kronenwett Ralf, Rohr Ulrich-Peter, Fenk Roland, Kliszewski Slawomir, Maercker Christian, Neubert Peter, Aivado Manuel, Koch Judith, Modlich Olga, Bojar Hans, Gattermann Norbert, Haas Rainer
Abstract excerpt
CD34+ hematopoietic stem cells are used clinically to support cytotoxic therapy, and recent studies raised hope that they could even serve as a cellular source for nonhematopoietic tissue engineering. Here, we examined in 18 volunteers the gene expressions of 1185 genes in highly enriched bone marrow CD34+ (BM-CD34+) or granulocyte-colony-stimulating factor-mobilized peripheral blood CD34+ (PB-CD34+) cells by...
Topics
- Antigens, CD34
- Apoptosis
- Blood Cells
- Bone Marrow Cells
- Cell Cycle Proteins
- Cluster Analysis
- DNA Replication
- DNA-Binding Proteins
- E2F Transcription Factors
- E2F1 Transcription Factor
- Gene Expression Profiling
- Genes, cdc