Article
Characterization of plasminogen variants in healthy subjects and plasminogen mutants in patients with inherited plasminogen deficiency by isoelectric focusing gel electrophoresis.
Thrombosis and haemostasis - 1 Aug 2004
Tefs Katrin, Georgieva Maria, Seregard Stefan, Tait Campbell R, Luchtman-Jones Lori, Ziegler Maike, Hügle Boris, Schuster Volker
Abstract excerpt
Plasmin(ogen) plays an important role in fibrinolysis and wound healing. Severe hypoplasminogenemia has recently been linked to ligneous conjunctivitis. Plasminogen (plg) is known as a polymorphic protein and most of these variants have been identified using isoelectric focusing (IEF) gel electrophoresis. Here, we studied common plg variants from healthy subjects and plg mutants from three patients with...
Topics
- Asparagine
- Conjunctivitis
- Female
- Genetic Variation
- Homozygote
- Humans
- Immunoblotting
- Isoelectric Focusing
- Male
- Mutation
- Pedigree
- Phenotype
- Plasminogen
- Polymorphism, Genetic