Article
Isoelectric focusing pattern of plasminogen mutants of patients with hypoplasminogenemia: correlation of in-vitro data with computer-predicted isoelectric points (pI).
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Sept 2011
Tefs Katrin, Ott-Gueorguieva Maria, Kobelt Louise, Ziegler Maike, Hintze Christian, Hügle Boris, Schuster Volker
Abstract excerpt
Plasminogen (plg), the circulating proenzyme of plasmin in blood, is a polymorphic protein and most of these natural variants have been identified using isoelectric focusing (IEF) gel electrophoresis. Here, we show that a rare plg gene polymorphism 504R/W is associated with IEF phenotype A3 on the protein level. One healthy individual with homozygous plg gene polymorphism 504W studied so far exhibited low normal...
Topics
- Algorithms
- Alleles
- Blood Coagulation Disorders
- Enzyme-Linked Immunosorbent Assay
- Female
- Gene Frequency
- Homozygote
- Humans
- Isoelectric Focusing
- Isoelectric Point
- Male
- Molecular Typing