Article
Isoelectric focusing pattern of plasminogen mutants of patients with hypoplasminogenemia: correlation of in-vitro data with computer-predicted isoelectric points (pI).
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Sept 2011
Tefs Katrin, Ott-Gueorguieva Maria, Kobelt Louise, Ziegler Maike, Hintze Christian, Hügle Boris, Schuster Volker
Abstract excerpt
Plasminogen (plg), the circulating proenzyme of plasmin in blood, is a polymorphic protein and most of these natural variants have been identified using isoelectric focusing (IEF) gel electrophoresis. Here, we show that a rare plg gene polymorphism 504R/W is associated with IEF phenotype A3 on the protein level. One healthy individual with homozygous plg gene polymorphism 504W studied so far exhibited low normal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.