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Identification of three novel plasminogen (PLG) gene mutations in a series of 23 patients with low PLG activity.

Thrombosis and haemostasis - 1 Mar 2011

Klammt Jürgen, Kobelt Louise, Aktas Dilek, Durak Ismet, Gokbuget Aslan, Hughes Quintin, Irkec Murat, Kurtulus Idil, Lapi Elisabetta, Mechoulam Hadas, Mendoza-Londono Roberto, Palumbo Joseph S, Steitzer Hansjörg, Tabbara Khalid F, Ozbek Zeynep, Pucci Neri, Sotomayor Talia, Sturm Marian, Drogies Tim, Ziegler Maike, Schuster Volker

Abstract excerpt

Inherited severe hypoplasminogenaemia is a multisystemic disorder leading to deficient extravascular fibrinolysis. As a clinical consequence wound healing capacity of mucous membranes is markedly impaired leading to ligneous conjunctivitis and several other manifestations. Here we report the molecular genetic and clinical findings on 23 new cases with severe hypoplasminogenaemia. Homozygous or...

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Identifiers

PMID: 21174000
DOI: 10.1160/TH10-04-0216

Genes

PLG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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