Mutations in PMR1 suppress oxidative damage in yeast cells lacking superoxide dismutase.

doi:10.1128/MCB.15.3.1382

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Mutations in PMR1 suppress oxidative damage in yeast cells lacking superoxide dismutase.

Molecular and cellular biology - 1 Mar 1995

Lapinskas P J, Cunningham K W, Liu X F, Fink G R, Culotta V C

Abstract excerpt

Mutants of Saccharomyces cerevisiae lacking a functional SOD1 gene encoding Cu/Zn superoxide dismutase (SOD) are sensitive to atmospheric levels of oxygen and are auxotrophic for lysine and methionine when grown in air. We have previously shown that these defects of SOD-deficient yeast cells can be overcome through mutations in either the BSD1 or BSD2 (bypass SOD defects) gene. In this study, the wild-type allele...

Topics

Adenosine Triphosphatases
Aerobiosis
Anaerobiosis
Calcium
Cloning, Molecular
Genes, Fungal
Genetic Complementation Test
Genotype
Lysine
Manganese
Methionine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis

Oxygen

Paraquat

Saccharomyces cerevisiae

Superoxide Dismutase

Suppression, Genetic

Zinc

Source

Open in PubMed Open full text

Identifiers

PMID: 7862131
DOI: 10.1128/MCB.15.3.1382
PMCID: PMC230362

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7862131-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in PMR1 suppress oxidative damage in yeast cells lacking superoxide dismutase.PMID 7862131Read ↗

Yeast lacking superoxide dismutase. Isolation of genetic suppressors.Semantic proximity Read ↗

Cu/Zn superoxide dismutase and the proton ATPase Pma1p of Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutations in Saccharomyces cerevisiae iron-sulfur cluster assembly genes and oxidative stress relevant to Cu,Zn superoxide dismutase.Semantic proximity Read ↗

A physiological role for Saccharomyces cerevisiae copper/zinc superoxide dismutase in copper buffering.Semantic proximity Read ↗

Suppression of oxidative damage by Saccharomyces cerevisiae ATX2, which encodes a manganese-trafficking protein that localizes to Golgi-like vesicles.Semantic proximity Read ↗

The requirement for yeast superoxide dismutase is bypassed through mutations in BSD2, a novel metal homeostasis gene.Semantic proximity Read ↗

Involvement of thioredoxin peroxidase type II (Ahp1p) of Saccharomyces cerevisiae in Mn2+ homeostasis.Semantic proximity Read ↗

SOD1 mutations cause hypersensitivity to high-pressure-induced oxidative stress in Saccharomyces cerevisiae.Semantic proximity Read ↗

Phenotypic screening of mutations in Pmr1, the yeast secretory pathway Ca2+/Mn2+-ATPase, reveals residues critical for ion selectivity and transport.Semantic proximity Read ↗

Mitochondrial protein oxidation in yeast mutants lacking manganese-(MnSOD) or copper- and zinc-containing superoxide dismutase (CuZnSOD): evidence that MnSOD and CuZnSOD have both unique and overlapping functions in protecting mitochondrial proteins from oxidative damage.Semantic proximity Read ↗

Negative control of heavy metal uptake by the Saccharomyces cerevisiae BSD2 gene.Semantic proximity Read ↗

Overexpression of human SOD1 in VDAC1-less yeast restores mitochondrial functionality modulating beta-barrel outer membrane protein genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.