Article
Mutations in PMR1 suppress oxidative damage in yeast cells lacking superoxide dismutase.
Molecular and cellular biology - 1 Mar 1995
Lapinskas P J, Cunningham K W, Liu X F, Fink G R, Culotta V C
Abstract excerpt
Mutants of Saccharomyces cerevisiae lacking a functional SOD1 gene encoding Cu/Zn superoxide dismutase (SOD) are sensitive to atmospheric levels of oxygen and are auxotrophic for lysine and methionine when grown in air. We have previously shown that these defects of SOD-deficient yeast cells can be overcome through mutations in either the BSD1 or BSD2 (bypass SOD defects) gene. In this study, the wild-type allele...
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