Article
The requirement for yeast superoxide dismutase is bypassed through mutations in BSD2, a novel metal homeostasis gene.
Molecular and cellular biology - 1 Nov 1994
Liu X F, Culotta V C
Abstract excerpt
Oxygen toxicity in Saccharomyces cerevisiae strains lacking superoxide dismutase can be suppressed through mutations in either the BSD1 or BSD2 gene. In this report, we demonstrate that the BSD2 gene normally functions in the homeostasis of heavy metal ions. A mutation in BSD2 not only reverses the aerobic defects of yeast strains lacking superoxide dismutase but also is associated with an increased sensitivity...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Chromosome Mapping
- Cloning, Molecular
- Copper
- DNA, Fungal
- Free Radicals
- Gene Deletion
- Genes, Fungal
- Homeostasis
- Metals