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Article

MyD88 plays a unique role in host defense but not arthritis development in Lyme disease.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2004

Bolz Devin D, Sundsbak Rhianna S, Ma Ying, Akira Shizuo, Kirschning Carsten J, Zachary James F, Weis John H, Weis Janis J

Abstract excerpt

To assess the contribution of TLR signaling in the host response to Borrelia burgdorferi, mice deficient in the common TLR adaptor protein, myeloid differentiation factor 88 (MyD88), were infected with B. burgdorferi. MyD88-deficient mice harbored extremely high levels of B. burgdorferi in tissues when compared with wild-type littermates and greater amounts of spirochetes in tissues than TLR2-deficient mice....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15265935
DOI: 10.4049/jimmunol.173.3.2003

Genes

TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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