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Article

Classically Restricted Human CD8+ T Lymphocytes Derived from Mycobacterium tuberculosis -Infected Cells: Definition of Antigenic Specificity

1 Jan 2001

Abstract excerpt

Previous studies in murine and human models have suggested an important role for HLA Ia-restricted CD8(+) T cells in host defense to Mycobacterium tuberculosis (Mtb). Therefore, understanding the Ags presented via HLA-Ia will be important in understanding the host response to Mtb and in rational vaccine design. We have used monocyte-derived dendritic cells in a limiting dilution analysis to generate Mtb-specific...

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PMID: 11123322
DOI: 10.4049/jimmunol.166.1.439

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Source receipt: pubmed, retrieved 7 Sept 2026.

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