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Article

Association between urokinase-plasminogen activator gene T4065C polymorphism and risk of mitral valve prolapse.

International journal of cardiology - 1 Aug 2004

Chou Hsiang-Tai, Chen Yng-Tay, Wu Jer-Yuarn, Tsai Fuu-Jen

Abstract excerpt

BACKGROUND: Abnormalities of collagen and elastic fibers were found in floppy mitral valves (FMV). Urokinase-plasminogen activator (PLAU) was suggested to be involved in the pathogenesis of elastin and collagen degradation in arterial aneurysm. The role of PLAU genetic variant in mitral valve prolapse (MVP) has not been studied. We, therefore, performed a case-controlled study investigating the possible relation...

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Source

Identifiers

PMID: 15262029
DOI: 10.1016/j.ijcard.2003.05.034

Genes

PLAU
MVP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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