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Article

Matrix metalloproteinase-1 mitral expression and -1607 1G/2G gene promoter polymorphism in mitral chordae tendinae rupture.

Translational research : the journal of laboratory and clinical medicine - 1 May 2013

Lin Tsung-Hsien, Yang Sheau-Fang, Chiu Chaw-Chi, Su Ho-Ming, Wang Chiao-Ling, Voon Wen-Chol, Lai Wen-Ter, Sheu Sheng-Hsiung

Abstract excerpt

Understanding the pathogenesis of mitral chordae tendinae rupture (MCTR) is essential for identification of risk factors. Mitral matrix metalloproteinase (MMP) triggers the signal cascade that instigates cardiac fibrosis, which may be a predisposing factor in MCTR. We investigated associations among MMP1 expression, MMP1 -1607 1G/2G polymorphism and mitral chordae tendinae rupture (MCTR). This study enrolled 185...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23116893
DOI: 10.1016/j.trsl.2012.10.002

Genes

MMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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