Article
Chondrogenic transdifferentiation of human dermal fibroblasts stimulated with cartilage-derived morphogenetic protein 1.
Tissue engineering. Part A - 1 May 2010
Yin Shuo, Cen Lian, Wang Chen, Zhao Guiqing, Sun Jian, Liu Wei, Cao Yilin, Cui Lei
Abstract excerpt
This study aimed to investigate the chondrogenic transdifferentiation potential of human dermal fibroblasts (DFs) by stimulation with cartilage-derived morphogenetic protein 1 (CDMP1). Using CDMP1 (100 ng/mL) we induced human DFs at passage 5 in both monolayer and micromass culture. Chondrogenic-specific markers were detected via immunochemistry, reverse transcription-polymerase chain reaction, and Western blot...
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