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Article

A Novel Cell Adhesion Region in Tropoelastin Mediates Attachment to Integrin αVβ5

30 Nov 2013

Abstract excerpt

Tropoelastin protein monomers assemble to form elastin. Cellular integrin αVβ3 binds RKRK at the C-terminal tail of tropoelastin. We probed cell interactions with tropoelastin by deleting the RKRK sequence to identify other cell-binding interactions within tropoelastin. We found a novel human dermal fibroblast attachment and spreading site on tropoelastin that is located centrally in the molecule. Inhibition...

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PMID: 24293364
DOI: 10.1074/jbc.m113.518381

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