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Article

Lack of association between polymorphisms of the toll-like receptor 4 gene and cerebral ischemia.

Journal of neurology - 1 Jul 2004

Reismann Peter, Lichy Christoph, Rudofsky Gottfried, Humpert Per M, Genius Just, Si Tuan-Dong, Dörfer Christof, Grau Armin J, Hamann Andreas, Hacke Werner, Nawroth Peter P, Bierhaus Angelika

Abstract excerpt

Toll-like receptor-4 (TLR4), an important mediator of the innate immune response, is expressed in atherosclerotic lesions. The common single nucleotide exchange (Asp299Gly) of the TLR4 gene has been previously reported to impair TLR4 function and to be associated with a decreased risk of carotid atherosclerosis. Therefore, we aimed to detect the potential impact of TLR4 genotypes on the risk of cerebral ischemia....

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Source

Identifiers

PMID: 15258789
DOI: 10.1007/s00415-004-0447-7

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Lack of association between polymorphisms of the toll-like receptor 4 gene and cerebral ischemia.PMID 15258789Read ↗

Toll-like receptor 4 gene Asp299Gly polymorphism in ischemic cerebrovascular disease: a meta-analysis.Semantic proximity Read ↗

Lack of the Toll-Like Receptor 4 Gene Polymorphisms Asp299Gly and Thr399ile in a Chinese Population.Semantic proximity Read ↗

Functional polymorphisms in toll-like receptor 4 are associated with worse outcome in acute ischemic stroke patients.Semantic proximity Read ↗

TLR4 rs1927911, but not TLR2 rs5743708, is associated with atherosclerotic cerebral infarction in the Southern Han population: a case-control study.Semantic proximity Read ↗

Lack of association between TLR4 Asp299Gly polymorphism and atherosclerosis: evidence from meta-analysis.Semantic proximity Read ↗

TLR4 Asp299Gly polymorphism is not associated with coronary artery stenosis.Semantic proximity Read ↗

Toll-like receptor 4 gene Asp299Gly polymorphism in myocardial infarction: a meta-analysis of 15,148 subjects.Semantic proximity Read ↗

The Roles of TLR Gene Polymorphisms in Atherosclerosis: A Systematic Review and Meta-Analysis of 35,317 Subjects.Semantic proximity Read ↗

Toll-like receptor 4 gene polymorphisms and acute coronary syndrome: no association in a Mexican population.Semantic proximity Read ↗

Association of the Toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events.Semantic proximity Read ↗

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