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Article

Functional polymorphisms in toll-like receptor 4 are associated with worse outcome in acute ischemic stroke patients.

Neuroreport - 28 May 2014

Weinstein Jonathan R, Schulze Juliane, Lee Richard V, Phillips Hunter, Zierath Dannielle, Tanzi Patricia, Shibata Dean, Cain Kevin C, Becker Kyra J

Abstract excerpt

Toll-like receptor-4 (TLR4) is important in neuroinflammation. Single nucleotide polymorphisms (SNPs) in TLR4, including 1063 A/G [Asp299Gly] and 1363 C/T [Thr399Ile], are associated with altered immune responses but their effect on acute ischemic stroke (AIS) outcome is unknown. We collected demographic, clinical, laboratory, radiologic, and genotype data on 113 AIS patients and performed multivariate analyses...

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Identifiers

PMID: 24784586
DOI: 10.1097/WNR.0000000000000140
PMCID: PMC4009512

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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