Article
Voluntary alcohol consumption is controlled via the neuropeptide Y Y1 receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Feb 2002
Thiele Todd E, Koh Ming Teng, Pedrazzini Thierry
Abstract excerpt
We have shown previously that voluntary ethanol consumption and resistance to ethanol-induced sedation are inversely related to neuropeptide Y (NPY) levels in NPY-knock-out (NPY(-/-)) and NPY-overexpressing mice. In the present report, we studied knock-out mice completely lacking the NPY Y1 receptor (Y1(-/-)) to further characterize the role of the NPY system in ethanol consumption and neurobiological responses...
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