Article
Genomic stability and wild-type p53 function of lymphoblastoid cells with germ-line p53 mutation.
Oncogene - 15 Jun 1995
Lalle P, Moyret-Lalle C, Wang Q, Vialle J M, Navarro C, Bressac-de Paillerets B, Magaud J P, Ozturk M
Abstract excerpt
Increased cancer risk associated with germ-line p53 mutation was linked to a deficit in the ability to maintain genomic stability. Accordingly, normal fibroblasts from cancer-prone individuals accumulate genomic aberrations with concomitant loss of wild-type p53 allele during in vitro culture. We...
Topics
- Alleles
- B-Lymphocytes
- Breast Neoplasms
- Cell Line
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA Damage
- G1 Phase
- Genes, p53
- Humans
- Karyotyping
- Mutation
- S Phase
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53