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Article

Genomic stability and wild-type p53 function of lymphoblastoid cells with germ-line p53 mutation.

Oncogene - 15 Jun 1995

Lalle P, Moyret-Lalle C, Wang Q, Vialle J M, Navarro C, Bressac-de Paillerets B, Magaud J P, Ozturk M

Abstract excerpt

Increased cancer risk associated with germ-line p53 mutation was linked to a deficit in the ability to maintain genomic stability. Accordingly, normal fibroblasts from cancer-prone individuals accumulate genomic aberrations with concomitant loss of wild-type p53 allele during in vitro culture. We tested whether such changes also occur in EBV-immortalized lymphoblastoid cells. Both normal and p53 germ-line mutant...

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PMID: 7784096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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