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Article

Chromosome instability is a predominant trait of fibroblasts from Li-Fraumeni families.

British journal of cancer - 1 Jun 1998

Boyle J M, Mitchell E L, Greaves M J, Roberts S A, Tricker K, Burt E, Varley J M, Birch J M, Scott D

Abstract excerpt

Previous work has indicated a role for p53 in cell cycle control, genomic stability and cellular responses to DNA-damaging agents. However, few data are available for human fibroblasts heterozygous for defined germline mutations in TP53. We report studies on 25 strains derived from 12 families with Li-Fraumeni syndrome (LFS) and 18 strains from normal volunteers. The families include three that are classical LFS...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 9649131
DOI: 10.1038/bjc.1998.364
PMCID: PMC2150396

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Chromosome instability is a predominant trait of fibroblasts from Li-Fraumeni families.PMID 9649131Read ↗

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