Chromosome instability is a predominant trait of fibroblasts from Li-Fraumeni families.

doi:10.1038/bjc.1998.364

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Article

Chromosome instability is a predominant trait of fibroblasts from Li-Fraumeni families.

British journal of cancer - 1 Jun 1998

Boyle J M, Mitchell E L, Greaves M J, Roberts S A, Tricker K, Burt E, Varley J M, Birch J M, Scott D

Abstract excerpt

Previous work has indicated a role for p53 in cell cycle control, genomic stability and cellular responses to DNA-damaging agents. However, few data are available for human fibroblasts heterozygous for defined germline mutations in TP53. We report studies on 25 strains derived from 12 families wi...

Topics

Adolescent
Adult
Aged
Child
Chromosome Aberrations
Female
Fibroblasts
Genes, p53
Germ-Line Mutation
Heterozygote
Humans
Li-Fraumeni Syndrome
Male
Middle Aged
Phenotype

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