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Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells

7 Jul 2004

Abstract excerpt

For cells on the path to carcinogenesis, the key to unlimited growth potential lies in overcoming the steady loss of telomeric sequence commonly referred to as the 'end-replication problem' that occurs with each cell division. Most human tumors have reactivated telomerase, a specialized reverse transcriptase that directs RNA-templated addition of telomeric repeats on to chromosomal termini. However, approximately...

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PMID: 15258249
DOI: 10.1093/nar/gkh691

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