Article
Insulin-like growth factor I gene microsatellite repeat, collagen type Ialpha1 gene Sp1 polymorphism, and bone disease in primary biliary cirrhosis.
European journal of gastroenterology & hepatology - 1 Aug 2004
Lakatos Peter Laszlo, Bajnok Eva, Tornai Istvan, Folhoffer Aniko, Horvath Andrea, Lakatos Peter, Habior Andrzej, Szalay Ferenc
Abstract excerpt
BACKGROUND: Genetic factors have been implicated in the pathogenesis of osteoporosis, a common disorder in primary biliary cirrhosis. Insulin-like growth factor I (IGF-I) gene microsatellite repeat polymorphism was found to be associated with osteoporosis in some studies, and collagen-Ialpha1 (COLIA1) Sp1 s allele was associated with lower bone mineral density in primary biliary cirrhosis. IGF-I treatment...
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