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Article

The COL1A1 SP1 polymorphism is associated with lower bone mineral density in patients treated with valproic acid.

Pharmacogenetics and genomics - 1 Mar 2016

Villegas-Martínez Irene, de-Miguel-Elízaga Irene, Carrasco-Torres Rubén, Marras Carlos, Canteras-Jordana Manuel, Yedra-Guzmán Maria J, Martínez-Villanueva Miriam, Tortosa-Conesa Diego, Martín-Fernández Javier

Abstract excerpt

OBJECTIVE: The aim of this study was to determine the possible relationship between the Sp1 polymorphism of gene COL1A1 and bone metabolism disorder in individuals with epilepsy. METHODS: To this end, we carried out an observational cross-sectional study on 64 patients in monotherapy with an antiepileptic drug. The patients were classified on the basis of the presence of the 's' allele of the COL1A1 Sp1...

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PMID: 26727275
DOI: 10.1097/FPC.0000000000000199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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