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Article

Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression.

Oncogene - 23 Mar 2000

Mussman J G, Horn H F, Carroll P E, Okuda M, Tarapore P, Donehower L A, Fukasawa K

Abstract excerpt

Centrosome hyperamplification and the consequential mitotic defects contribute to chromosome instability in cancers. Loss or mutational inactivation of p53 has been shown to induce chromosome instability through centrosome hyperamplification. It has recently been found that Cdk2-cyclin E is involved in the initiation of centrosome duplication, and that constitutive activation of Cdk2-cyclin E results in the...

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PMID: 10763820
DOI: 10.1038/sj.onc.1203460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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