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Article

Mechanistic similarities between cultured cell models of cystic fibrosis and niemann-pick type C.

American journal of respiratory cell and molecular biology - 1 Nov 2004

White Nicole M, Corey Deborah A, Kelley Thomas J

Abstract excerpt

Recent data demonstrate that inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase restores normal signal transducer and activator of transcription-1 and inducible nitric oxide synthase expression regulation in cystic fibrosis (CF) cells through the modulation of RhoA function. These findings lead to the hypothesis that alterations in the cholesterol synthesis pathway may be an initiating factor in CF-related...

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Source

Identifiers

PMID: 15256387
DOI: 10.1165/rcmb.2004-0117OC

Genes

SMAD3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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