Article
Complementation studies in human and feline Niemann-Pick type C disease.
Molecular genetics and metabolism - 1 Feb 1999
Somers K L, Wenger D A, Royals M A, Carstea E D, Connally H E, Kelly T, Kimball R, Thrall M A
Abstract excerpt
Complementation studies were performed to determine if the gene responsible for the major form of human Niemann-Pick type C disease (NPC) and a feline model of NPC are orthologous. Cell fusions between human NPC and feline NPC fibroblasts were conducted to assess whether the multinucleated heterokaryons that were formed showed a reversal of the NPC phenotype. Cultured fibroblasts from NPC-affected humans and...
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