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Article

PKC activation in Niemann pick C1 cells restores subcellular cholesterol transport.

PloS one - 1 Jan 2013

Tamari Farshad, Chen Fannie W, Li Chunlei, Chaudhari Jagrutiben, Ioannou Yiannis A

Abstract excerpt

Activation of protein kinase C (PKC) has previously been shown to ameliorate the cholesterol transport defect in Niemann Pick Type C1 (NPC1) cells, presumably by increasing the soluble levels of one of its substrates, vimentin. This activity would then restore the vimentin cycle in these cells and allow vimentin-dependent retrograde transport to proceed. Here, we further investigate the effects of PKC activation...

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Identifiers

PMID: 23977398
DOI: 10.1371/journal.pone.0074169
PMCID: PMC3744505

Genes

NPC1

Provenance

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