Article
Role of caveolae in ouabain-induced proliferation of cultured vascular smooth muscle cells of the synthetic phenotype.
American journal of physiology. Heart and circulatory physiology - 1 Nov 2004
Liu Lijun, Abramowitz Joel, Askari Amir, Allen Julius C
Abstract excerpt
We have shown earlier that low concentrations of ouabain that do not perturb the ionic milieu can initiate proliferation of vascular smooth muscle cells (VSMCs) in the synthetic phenotype from three different species: canine, rodent, and human. This effect occurs by activation of Src and the epidermal growth factor receptor (EGFR), and thus supports the concept of an additional, nonionic, transducing function of...
Topics
- Animals
- Caveolae
- Cell Division
- Cells, Cultured
- Dogs
- Enzyme Inhibitors
- ErbB Receptors
- Humans
- Intracellular Signaling Peptides and Proteins
- Muscle, Smooth, Vascular
- Myocytes, Smooth Muscle
- Ouabain
- Phenotype
- Protein Isoforms
- Rats
- Sodium-Potassium-Exchanging ATPase
- Species Specificity
- src-Family Kinases