Article
Endothelial venodilator response in carriers of genetic polymorphisms involved in NO synthesis and degradation.
British journal of clinical pharmacology - 1 Aug 2004
Fricker Ruth, Hesse Christiane, Weiss Johanna, Tayrouz Yorki, Hoffmann Michael M, Unnebrink Kristina, Mansmann Ulrich, Haefeli Walter E
Abstract excerpt
AIMS: Polymorphisms of the NOSIII gene and of the CYBA gene have been associated with a number of pathological conditions such as arterial hypertension, coronary artery disease, and myocardial infarction. Because endothelium-dependent vasodilation is impaired in these disorders, we hypothesized that polymorphisms of NOSIII or CYBA might modulate endothelial function of venous capacitance vessels already before...
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