Article
Analysis of a Drosophila amplicon in follicle cells highlights the diversity of metazoan replication origins.
Proceedings of the National Academy of Sciences of the United States of America - 4 Oct 2011
Kim Jane C, Orr-Weaver Terry L
Abstract excerpt
To investigate the properties of metazoan replication origins, recent studies in cell culture have adopted the strategy of identifying origins using genome-wide approaches and assessing correlations with such features as transcription and histone modifications. Drosophila amplicon in follicle cells (DAFCs), genomic regions that undergo repeated rounds of DNA replication to increase DNA copy number, serve as...
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