Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bone Morphogenetic Protein 2-Induced Osteoblast Differentiation Requires Smad-Mediated Down-Regulation of Cdk6

14 Jul 2004

Abstract excerpt

Because a temporal arrest in the G(1) phase of the cell cycle is thought to be a prerequisite for cell differentiation, we investigated cell cycle factors that critically influence the differentiation of mouse osteoblastic MC3T3-E1 cells induced by bone morphogenetic protein 2 (BMP-2), a potent inducer of osteoblast differentiation. Of the G(1) cell cycle factors examined, the expression of cyclin-dependent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Metabolism and Diseases
Share to Cancer-related Molecular Pathways
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15254224
DOI: 10.1128/mcb.24.15.6560-6568.2004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bone Morphogenetic Protein 2-Induced Osteoblast Differentiation Requires Smad-Mediated Down-Regulation of Cdk6PMID 15254224Read ↗

The role of CDK8 in mesenchymal stem cells in controlling osteoclastogenesis and bone homeostasisSemantic proximity Read ↗

Cell cycle regulators control mesoderm specification in human pluripotent stem cellsSemantic proximity Read ↗

BMP-2 promotes differentiation of osteoblasts and chondroblasts in Runx2-deficient cell lines.Semantic proximity Read ↗

The Bone-specific Expression of Runx2 Oscillates during the Cell Cycle to Support a G1-related Antiproliferative Function in OsteoblastsSemantic proximity Read ↗

p21WAF1/CIP1 Acts as a Brake in Osteoblast DifferentiationSemantic proximity Read ↗

Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2.Semantic proximity Read ↗

U0126 promotes osteogenesis of rat bone-marrow-derived mesenchymal stem cells by activating BMP/Smad signaling pathway.Semantic proximity Read ↗

Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma.Semantic proximity Read ↗

Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription.Semantic proximity Read ↗

Connective Tissue Growth Factor (CTGF/CCN2) Negatively Regulates BMP‐2 Induced Osteoblast Differentiation and SignalingSemantic proximity Read ↗

Role of Smad1 and Smad4 proteins in the induction of p21WAF1,Cip1 during bone morphogenetic protein-induced growth arrest in human breast cancer cellsSemantic proximity Read ↗

Bone Morphogenetic Protein (BMP)-6 Signaling and BMP Antagonist Noggin in Prostate CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.