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Article

p21WAF1/CIP1 Acts as a Brake in Osteoblast Differentiation

1 May 2003

Abstract excerpt

Continuous fibroblast growth factor signaling inhibits the differentiation of primary osteoblasts and osteoblastic cell lines. We studied the expression of several cell cycle regulatory molecules in response to fibroblast growth factor, and found that fibroblast growth factor strongly upregulates the expression of p21(WAF1/CIP1), a CDK inhibitor that has also been implicated in the regulation of apoptosis and...

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PMID: 12733720
DOI: 10.1359/jbmr.2003.18.5.818

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