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Article

Application of a new method for GWAS in a related case/control sample with known pedigree structure: identification of new loci for nephrolithiasis.

PLoS genetics - 20 Jan 2011

Tore Silvia, Casula Stefania, Casu Giuseppina, Concas Maria Pina, Pistidda Paola, Persico Ivana, Sassu Alessandro, Maestrale Giovanni Battista, Mele Caterina, Caruso Maria Rosa, Bonerba Bibiana, Usai Paolo, Deiana Ivo, Thornton Timothy, Pirastu Mario, Forabosco Paola

Abstract excerpt

In contrast to large GWA studies based on thousands of individuals and large meta-analyses combining GWAS results, we analyzed a small case/control sample for uric acid nephrolithiasis. Our cohort of closely related individuals is derived from a small, genetically isolated village in Sardinia, with well-characterized genealogical data linking the extant population up to the 16(th) century. It is expected that the...

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PMID: 21283782
DOI: 10.1371/journal.pgen.1001281
PMCID: PMC3024262

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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