Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL-1R and MyD88 signalling in CD4+ T cells promote Th17 immunity and atherosclerosis.

Cardiovascular research - 1 Jan 2018

Engelbertsen Daniel, Rattik Sara, Wigren Maria, Vallejo Jenifer, Marinkovic Goran, Schiopu Alexandru, Björkbacka Harry, Nilsson Jan, Bengtsson Eva

Abstract excerpt

Aims: The role of CD4+ T cells in atherosclerosis has been shown to be dependent on cytokine cues that regulate lineage commitment into mature T helper sub-sets. In this study, we tested the roles of IL-1R1 and MyD88 signalling in CD4+ T cells in atherosclerosis. Methods and results: We transferred apoe-/-myd88+/+ or apoe-/-myd88-/- CD4+ T cells to T- and B-cell-deficient rag1-/-apoe-/- mice fed high fat diet....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adoptive Transfer
Share to Aorta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aortic Diseases

Share to Interleukin-17

Share to Mice, Knockout, ApoE

Share to Myeloid Differentiation Factor 88

Share to Plaque, Atherosclerotic

Share to Th17 Cells

Source

Identifiers

PMID: 29036304
DOI: 10.1093/cvr/cvx196

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL-1R and MyD88 signalling in CD4+ T cells promote Th17 immunity and atherosclerosis.PMID 29036304Read ↗

Smooth Muscle Cell-Derived Interleukin-17C Plays an Atherogenic Role via the Recruitment of Proinflammatory Interleukin-17A+ T Cells to the Aorta.Semantic proximity Read ↗

CD147 Sparks Atherosclerosis by Driving M1 Phenotype and Impairing Efferocytosis.Semantic proximity Read ↗

IL-17A Influences Essential Functions of the Monocyte/Macrophage Lineage and Is Involved in Advanced Murine and Human AtherosclerosisSemantic proximity Read ↗

Interleukin-17: friend or foe in atherosclerosis?Semantic proximity Read ↗

Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E.Semantic proximity Read ↗

T Cells in Atherosclerosis: Key Players in the Pathogenesis of Vascular DiseaseSemantic proximity Read ↗

Toll-Like Receptor 9 Inactivation Alleviated Atherosclerotic Progression and Inhibited Macrophage Polarized to M1 Phenotype in ApoE-/- Mice.Semantic proximity Read ↗

The pleiotropic role of interleukin-17 in atherosclerosis.Semantic proximity Read ↗

Tc17 CD8+ T cells accumulate in murine atherosclerotic lesions, but do not contribute to early atherosclerosis development.Semantic proximity Read ↗

In Vitro Differentiation of Naïve CD4⁺ T Cells: A Tool for Understanding the Development of Atherosclerosis.Semantic proximity Read ↗

Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy.Semantic proximity Read ↗

Impairment of the programmed cell death-1 pathway increases atherosclerotic lesion development and inflammation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.