Article
Systematic screen of Schizosaccharomyces pombe deletion collection uncovers parallel evolution of the phosphate signal transduction pathway in yeasts.
Eukaryotic cell - 1 Feb 2011
Henry Theresa C, Power Juliette E, Kerwin Christine L, Mohammed Aishat, Weissman Jonathan S, Cameron Dale M, Wykoff Dennis D
Abstract excerpt
The phosphate signal transduction (PHO) pathway, which regulates genes in response to phosphate starvation, is well defined in Saccharomyces cerevisiae. We asked whether the PHO pathway was the same in the distantly related fission yeast Schizosaccharomyces pombe. We screened a deletion collection for mutants aberrant in phosphatase activity, which is primarily a consequence of pho1(+) transcription. We...
Topics
- Acid Phosphatase
- Carbon
- Epistasis, Genetic
- Evolution, Molecular
- Fungal Proteins
- Gene Deletion
- Gene Expression Profiling
- Gene Expression Regulation, Fungal
- Intracellular Signaling Peptides and Proteins