Article
Chymase gene (CMA1) polymorphisms in Dutch and Japanese sarcoidosis patients.
Respiration; international review of thoracic diseases - 1 Jan 2006
Kruit Adrian, Grutters Jan C, Ruven Henk J T, Sato Hiroe, Izumi Takateru, Nagai Sonoko, Welsh Kenneth I, du Bois Roland M, van den Bosch Jules M M
Abstract excerpt
BACKGROUND: Chymase is released from mast cells following activation. Evidence suggests that chymase plays an important role in tissue injury and remodeling of the lungs, heart and skin. OBJECTIVE: We postulated that chymase gene (CMA1) polymorphisms are associated with pulmonary fibrosis in Dutch and with cardiac and skin involvement in Japanese sarcoidosis patients. PATIENTS AND METHODS: Dutch (n = 153) and...
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