Article
Human T cell clones specific for heterogeneous nuclear ribonucleoprotein A2 autoantigen from connective tissue disease patients assist in autoantibody production.
Arthritis and rheumatism - 1 Jul 2004
Greidinger Eric L, Gazitt Tal, Jaimes Kimberly F, Hoffman Robert W
Abstract excerpt
OBJECTIVE: To identify and characterize human T cells reactive with heterogeneous nuclear RNP A2 (hnRNP A2) antigen, and to determine the ability of hnRNP-reactive T cells to assist in the production of human autoantibodies. METHODS: T cells from patients with high serum levels of anti-hnRNP IgG autoantibody were stimulated with an hnRNP recombinant fusion protein, and the cells were cloned by limiting dilution....
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