Autoantibodies to the A/B Proteins of the Heterogeneous Nuclear Ribonucleoprotein Complex: Novel Tools for the Diagnosis of Rheumatic Diseases

Abstract excerpt

Heterogeneous nuclear ribonucleoprotein (hnRNP) complexes are major constituents of the spliceosome. They are composed of approximately 30 different proteins which can bind to nascent pre-mRNA. Among these, the hnRNP-A/B proteins form a subgroup of highly related proteins: their N-terminal halves consist of two adjacent RNA-binding domains, whereas the C-terminal halves contain almost 50% glycine residues. These...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to RNA and protein synthesis mechanisms
• Share to RNA Research and Splicing
• Share to Viral Infections and Immunology Research