Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of intermolecular/intrastructural B- and T-cell determinants in the diversification of autoantibodies to ribonucleoprotein particles.

15 Dec 1993

Abstract excerpt

The U1 small nuclear ribonucleoprotein (sn-RNP) particle, which consists of the U1 small RNA and multiple polypeptides, is a central target of the autoimmune response in systemic lupus erythematosus. Autoantibodies to the individual proteins of the U1 snRNP typically co-occur in patients with systemic lupus erythematosus, an observation reconciled by postulating that the intact RNA-protein complex serves as the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Galectins and Cancer Biology
Share to Monoclonal and Polyclonal Antibodies Research
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8265662
DOI: 10.1073/pnas.90.24.12010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of intermolecular/intrastructural B- and T-cell determinants in the diversification of autoantibodies to ribonucleoprotein particles.PMID 8265662Read ↗

B cells process and present lupus autoantigens that initiate autoimmune T cell responses.Semantic proximity Read ↗

Distinctive immune response patterns of human and murine autoimmune sera to U1 small nuclear ribonucleoprotein C protein.Semantic proximity Read ↗

Pathogenesis of systemic lupus erythematosus revisited 2011: end organ resistance to damage, autoantibody initiation and diversification, and HLA-DR.Semantic proximity Read ↗

The U1‐snRNP complex: structural properties relating to autoimmune pathogenesis in rheumatic diseasesSemantic proximity Read ↗

Autoantibodies to the A/B Proteins of the Heterogeneous Nuclear Ribonucleoprotein Complex: Novel Tools for the Diagnosis of Rheumatic DiseasesSemantic proximity Read ↗

B and T Cell Responses to the Spliceosomal Heterogeneous Nuclear Ribonucleoproteins A2 and B1 in Normal and Lupus MiceSemantic proximity Read ↗

Determinant spreading: lessons from animal models and human diseaseSemantic proximity Read ↗

Epitope patterns of anti-RNP antibodies in rheumatic diseases. Evidence for an antigen-driven autoimmune response.Semantic proximity Read ↗

Cloned human TCR from patients with autoimmune disease can respond to two structurally distinct autoantigens.Semantic proximity Read ↗

Intra- and intermolecular spreading of autoimmunity involving the nuclear self-antigens La (SS-B) and Ro (SS-A).Semantic proximity Read ↗

B cell epitope on the U1 snRNP-C autoantigen contains a sequence similar to that of the herpes simplex virus protein.Semantic proximity Read ↗

Analysis of human T cell and B cell responses against U small nuclear ribonucleoprotein 70-kd, B, and D polypeptides among patients with systemic lupus erythematosus and mixed connective tissue disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.