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Article

Hyperplastic polyps and DNA microsatellite unstable cancers of the colorectum

1 Oct 2000

Abstract excerpt

Although the scientific and clinical rationale for classifying colorectal cancer according to mechanisms underlying genetic instability is well supported, little is known of the early morphogenesis of sporadic cancer showing high levels of DNA microsatellite instability (MSI-H). Evidence is accumulating that the traditional adenoma-carcinoma sequence may not apply to sporadic MSI-H colorectal cancer. The serrated...

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Identifiers

PMID: 11012735
DOI: 10.1046/j.1365-2559.2000.01028.x

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