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Article

Role of Mutant CFTR in Hypersusceptibility of Cystic Fibrosis Patients to Lung Infections

5 Jan 1996

Abstract excerpt

Cystic fibrosis (CF) patients are hypersusceptible to chronic Pseudomonas aeruginosa lung infections. Cultured human airway epithelial cells expressing the delta F508 allele of the cystic fibrosis transmembrane conductance regulator (CFTR) were defective in uptake of P. aeruginosa compared with cells expressing the wild-type allele. Pseudomonas aeruginosa lipopolysaccharide (LPS)-core oligosaccharide was...

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PMID: 8539601
DOI: 10.1126/science.271.5245.64

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Source receipt: pubmed, retrieved 7 Sept 2026.

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