Article
Is the gene encoding Chibby implicated as a tumour suppressor in colorectal cancer ?
BMC cancer - 9 Jul 2004
Gad Sophie, Teboul David, Lièvre Astrid, Goasguen Nicolas, Berger Anne, Beaune Philippe, Laurent-Puig Pierre
Abstract excerpt
BACKGROUND: A novel member of the Wnt signalling pathway, Chibby, was recently identified. This protein inhibits Wnt/beta-catenin mediated transcriptional activation by competing with Lef-1 (the transcription factor and target of beta-catenin) to bind to beta-catenin. This suggests that Chibby could be a tumour suppressor protein. The C22orf2 gene coding Chibby is located on chromosome 22, a region recurrently...
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