Article
[Localization of a tumor suppressor gene distal to D22S270 in colorectal cancers].
Gastroenterologie clinique et biologique - 1 Jan 1997
Duriez C, Schmitz A, Fouchet P, Buecher B, Thuille B, Lerebours F, Léger R, Boman F, Fléjou J F, Monges G, Paraf F, Bedossa P, Sabourin J C, Salmon R J, Laurent-Puig P, Thomas G, Olschwang S
Abstract excerpt
Recurrent allelic losses on chromosome 22q have been reported in colorectal cancer, distal to the NF2 gene, suggesting that another tumor suppressor gene might be involved. We report here the typing of 256 sporadic colorectal tumors and 18 colonic cancer cell lines using a set of chromosome 22 polymorphisms, ranging from 20 to 45. A panel of somatic cell hybrids, that allows to distinguish 11 bins in the 22q13...
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