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Article

The abnormal spindle protein is required for germ cell mitosis and oocyte differentiation during Drosophila oogenesis.

Experimental cell research - 1 Aug 2004

Riparbelli Maria Giovanna, Massarelli Chiara, Robbins Leonard G, Callaini Giuliano

Abstract excerpt

In this study, we present evidence that the asp function is required in oogenesis for germline cell divisions as well as for cyst polarity and oocyte differentiation. Consistent with previously described roles in spindle organization during Drosophila meiosis and mitosis, asp mutation leads to severe defects in spindle microtubule organization within the germarium. The mitotic spindles of the mutant cystocytes...

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Identifiers

PMID: 15242765
DOI: 10.1016/j.yexcr.2004.03.054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The abnormal spindle protein is required for germ cell mitosis and oocyte differentiation during Drosophila oogenesis.PMID 15242765Read ↗

The drosophila protein asp is involved in microtubule organization during spindle formation and cytokinesis.Semantic proximity Read ↗

A requirement for the Abnormal Spindle protein to organise microtubules of the central spindle for cytokinesis in Drosophila.Semantic proximity Read ↗

Mutations at the asp locus of Drosophila lead to multiple free centrosomes in syncytial embryos, but restrict centrosome duplication in larval neuroblasts.Semantic proximity Read ↗

Abnormal spindle protein, Asp, and the integrity of mitotic centrosomal microtubule organizing centers.Semantic proximity Read ↗

The Drosophila gamma-tubulin small complex subunit Dgrip84 is required for structural and functional integrity of the spindle apparatus.Semantic proximity Read ↗

Spectrosomes and fusomes anchor mitotic spindles during asymmetric germ cell divisions and facilitate the formation of a polarized microtubule array for oocyte specification in Drosophila.Semantic proximity Read ↗

Orbit/Mast, the CLASP orthologue of Drosophila, is required for asymmetric stem cell and cystocyte divisions and development of the polarised microtubule network that interconnects oocyte and nurse cells during oogenesis.Semantic proximity Read ↗

Abnormal meiotic spindles cause a cascade of defects during spermatogenesis in asp males of Drosophila.Semantic proximity Read ↗

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Asymmetric positioning and organization of the meiotic spindle of mouse oocytes requires CDC42 function.Semantic proximity Read ↗

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