Article
Estrogen-metabolizing gene polymorphisms in the assessment of breast carcinoma risk and fibroadenoma risk in Caucasian women.
Cancer - 15 Jul 2004
Hefler Lukas A, Tempfer Clemens B, Grimm Christoph, Lebrecht Antje, Ulbrich Eva, Heinze Georg, Leodolter Sepp, Schneeberger Christian, Mueller Manfred W, Muendlein Axel, Koelbl Heinz
Abstract excerpt
BACKGROUND: Genes encoding enzymes involved in estrogen metabolism are held to be candidate genes for associations with breast disease. In these candidate genes, no critical combination of single-nucleotide polymorphisms (SNPs) for assessing breast carcinoma risk has been reported to date. METHODS: In a large case-control study, the authors investigated 10 estrogen-metabolizing SNPs in 396 patients with breast...
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