Article
Ten estrogen-related polymorphisms and endometriosis: a study of multiple gene-gene interactions.
Obstetrics and gynecology - 1 Nov 2005
Huber Ambros, Keck Christoph C, Hefler Lukas A, Schneeberger Christian, Huber Johannes C, Bentz Eva-Katrin, Tempfer Clemens B
Abstract excerpt
OBJECTIVE: Genetic as well as hormonal factors are known to influence the development and clinical course of endometriosis. We aimed to investigate the association among 10 single nucleotide polymorphisms (SNPs) involved in the estrogen metabolism and endometriosis and to develop a multiple genetic model. METHODS: In a case-control study, we investigated the genotype frequencies of 10 estrogen metabolizing SNPs...
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