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Estrogen metabolism-related genes and breast cancer risk: the multiethnic cohort study.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Aug 2005

Le Marchand Loïc, Donlon Timothy, Kolonel Laurence N, Henderson Brian E, Wilkens Lynne R

Abstract excerpt

Common polymorphisms in genes that affect estrogen levels may be associated with breast cancer risk. We investigated the associations between breast cancer and sequence variants in several genes in the estradiol/estrone metabolism pathway (CYP1A1*2A, CYP1A2*1F, CYP1B1 Leu432Val, CYP3A4*1B, COMT Val158Met, SULT1A1Arg213His) as well as the Arg554Lys variant in AHR (a transcription factor for CYP1A1, CYP1A2, and...

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Identifiers

PMID: 16103451
DOI: 10.1158/1055-9965.EPI-05-0076

Genes

AHR
COMT

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