Article
C34T AMP deaminase 1 gene mutation protects cardiac function in donors.
Transplantation - 27 May 2004
Yacoub Magdi H, Yuen Ada H Y, Kalsi Kameljit K, Birks Emma J, Taegtmeyer Anne, Barton Paul J, Johnson Philip H, Suzuki Ken, Smolenski Ryszard T
Abstract excerpt
Dysfunction of the donor heart is an important clinical problem that could be affected by genetic factors. We tested the hypothesis that possession of the C34T nonsense mutation in AMPD1 gene, which is known to improve survival in chronic heart failure, protects against cardiac dysfunction in donors. Genetic analysis for C34T mutation was performed by single-stranded conformational polymorphism (SSCP) in 22 donor...
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