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Article

Genetic variation in CYP11B2 and AT1R influences heart rate variability conditional on sodium excretion.

Hypertension (Dallas, Tex. : 1979) - 1 Aug 2004

Stolarz Katarzyna, Staessen Jan A, Kawecka-Jaszcz Kalina, Brand Eva, Bianchi Giuseppe, Kuznetsova Tatiana, Tikhonoff Valérie, Thijs Lutgard, Reineke Thomas, Babeanu Speranta, Casiglia Edoardo, Fagard Robert, Filipovský Jan, Peleska Jan, Nikitin Yuri, Struijker-Boudier Harry, Grodzicki Tomasz

Abstract excerpt

Sympathetic tone increases with stimulation of the renin-angiotensin system and is under the influence of salt intake. In the European Project On Genes in Hypertension (EPOGH), we investigated whether polymorphisms in the genes encoding aldosterone synthase (CYP11B2 C-344T) and the type-1 angiotensin II receptor (AT1R A1166C) affect the autonomic modulation of heart rate at varying levels of salt intake. We...

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Identifiers

PMID: 15238568
DOI: 10.1161/01.HYP.0000135846.91124.a5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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