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Anaplasma phagocytophilum AnkA binds to granulocyte DNA and nuclear proteins

4 May 2004

Abstract excerpt

Human granulocytic anaplasmosis (HGA) is caused by the obligate intracellular bacterium Anaplasma phagocytophilum. The bacterium infects, survives, propagates in, and alters neutrophil phenotype, indicating unique survival mechanisms. AnkA is the only known A. phagocytophilum component that gains access beyond neutrophil vacuoles and is transported to the infected host cell nucleus. The ability of native and...

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PMID: 15236641
DOI: 10.1111/j.1462-5822.2004.00400.x

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