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Anaplasma phagocytophilum AFAP targets the host nucleolus and inhibits induced apoptosis

7 Jan 2025

Abstract excerpt

Anaplasma phagocytophilum, the etiologic agent of human granulocytic anaplasmosis (HGA), is an obligate intracellular Gram-negative bacterium. During infection, A. phagocytophilum transfers its type IV secretion system (T4SS) effector proteins into host cells to manipulate cellular processes. AFAP (an actin filament-associated Anaplasma phagocytophilum protein) was identified as a T4SS effector protein and found...

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PMID: 39839117
DOI: 10.3389/fmicb.2024.1533640

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