Article
Kras(G12D) induces EGFR-MYC cross signaling in murine primary pancreatic ductal epithelial cells.
Oncogene - 21 Jul 2016
Diersch S, Wirth M, Schneeweis C, Jörs S, Geisler F, Siveke J T, Rad R, Schmid R M, Saur D, Rustgi A K, Reichert M, Schneider G
Abstract excerpt
Epidermal growth factor receptor (EGFR) signaling has a critical role in oncogenic Kras-driven pancreatic carcinogenesis. However, the downstream targets of this signaling network are largely unknown. We developed a novel model system utilizing murine primary pancreatic ductal epithelial cells (PDECs), genetically engineered to allow time-specific expression of oncogenic Kras(G12D) from the endogenous promoter....
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