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Article

Transforming growth factor alpha activates Ha-Ras in human pancreatic cancer cells with Ki-ras mutations.

Gastroenterology - 1 Jun 1999

Seufferlein T, Van Lint J, Liptay S, Adler G, Schmid R M

Abstract excerpt

BACKGROUND & AIMS: The aim of this study was to identify signaling pathways that mediate cell proliferation in response to a Ras-activating growth factor, transforming growth factor (TGF)-alpha, in two pancreatic cancer cell lines with constitutively active Ki-Ras, MiaPaCa-2, and Panc-1. METHODS: ERK1/-2- and p90(rsk) activation were determined by immune complex kinase assays. AP-1 and E74 activation were...

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PMID: 10348828
DOI: 10.1016/s0016-5085(99)70509-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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